Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning
- 作者: Vengerovich N.1, Yudin M.1, Bykov V.1, Nikiforov A.1, Aleshina O.1, Kuz’min A.1, Ustinova T.1, Gadzikovskii S.2
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隶属关系:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Silver-Farm Innovative Pharmaceutical Companyss
- 期: 卷 163, 编号 6 (2017)
- 页面: 737-741
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239224
- DOI: https://doi.org/10.1007/s10517-017-3892-x
- ID: 239224
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详细
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED50 fentanyl (anesthetic effect), we studied the effects of naloxone—sodium alginate complex on the dynamics of CO2 concentration in the expired air. It was shown that treatment with the developed microencapsulated naloxone after fentanyl injection allowed reducing the therapeutic dose of the antagonist by more than 2 times and eliminated the necessity of repeated injections.
作者简介
N. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
M. Yudin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
V. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
A. Nikiforov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
O. Aleshina
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
A. Kuz’min
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
T. Ustinova
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
俄罗斯联邦, Moscow
S. Gadzikovskii
Silver-Farm Innovative Pharmaceutical Companyss
Email: ng@vengerovich.ru
俄罗斯联邦, St. Petersburg
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