Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning
- Autores: Vengerovich N.1, Yudin M.1, Bykov V.1, Nikiforov A.1, Aleshina O.1, Kuz’min A.1, Ustinova T.1, Gadzikovskii S.2
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Afiliações:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Silver-Farm Innovative Pharmaceutical Companyss
- Edição: Volume 163, Nº 6 (2017)
- Páginas: 737-741
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239224
- DOI: https://doi.org/10.1007/s10517-017-3892-x
- ID: 239224
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Resumo
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED50 fentanyl (anesthetic effect), we studied the effects of naloxone—sodium alginate complex on the dynamics of CO2 concentration in the expired air. It was shown that treatment with the developed microencapsulated naloxone after fentanyl injection allowed reducing the therapeutic dose of the antagonist by more than 2 times and eliminated the necessity of repeated injections.
Sobre autores
N. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Autor responsável pela correspondência
Email: ng@vengerovich.ru
Rússia, Moscow
M. Yudin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
V. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
A. Nikiforov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
O. Aleshina
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
A. Kuz’min
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
T. Ustinova
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, Moscow
S. Gadzikovskii
Silver-Farm Innovative Pharmaceutical Companyss
Email: ng@vengerovich.ru
Rússia, St. Petersburg