Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning
- Authors: Vengerovich N.G.1, Yudin M.A.1, Bykov V.N.1, Nikiforov A.S.1, Aleshina O.I.1, Kuz’min A.A.1, Ustinova T.M.1, Gadzikovskii S.V.2
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Affiliations:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Silver-Farm Innovative Pharmaceutical Companyss
- Issue: Vol 163, No 6 (2017)
- Pages: 737-741
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239224
- DOI: https://doi.org/10.1007/s10517-017-3892-x
- ID: 239224
Cite item
Abstract
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED50 fentanyl (anesthetic effect), we studied the effects of naloxone—sodium alginate complex on the dynamics of CO2 concentration in the expired air. It was shown that treatment with the developed microencapsulated naloxone after fentanyl injection allowed reducing the therapeutic dose of the antagonist by more than 2 times and eliminated the necessity of repeated injections.
About the authors
N. G. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Author for correspondence.
Email: ng@vengerovich.ru
Russian Federation, Moscow
M. A. Yudin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
V. N. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
A. S. Nikiforov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
O. I. Aleshina
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
A. A. Kuz’min
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
T. M. Ustinova
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Russian Federation, Moscow
S. V. Gadzikovskii
Silver-Farm Innovative Pharmaceutical Companyss
Email: ng@vengerovich.ru
Russian Federation, St. Petersburg