Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning
- Авторы: Vengerovich N.1, Yudin M.1, Bykov V.1, Nikiforov A.1, Aleshina O.1, Kuz’min A.1, Ustinova T.1, Gadzikovskii S.2
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Учреждения:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Silver-Farm Innovative Pharmaceutical Companyss
- Выпуск: Том 163, № 6 (2017)
- Страницы: 737-741
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239224
- DOI: https://doi.org/10.1007/s10517-017-3892-x
- ID: 239224
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Аннотация
We compared samples of microencapsulated naloxone prepared by using spray drying technique. 2-Hydroxypropyl-β-cyclodextrin, sodium alginate, polycaprolactone, and carboxymethyl cellulose were used as the carriers. It was found that the combination of naloxone with sodium alginate was characterized by the highest naloxone content in the matrix and the lowest release rate (100% release time was 60 min). Using the model of respiratory disturbances caused by 10 ED50 fentanyl (anesthetic effect), we studied the effects of naloxone—sodium alginate complex on the dynamics of CO2 concentration in the expired air. It was shown that treatment with the developed microencapsulated naloxone after fentanyl injection allowed reducing the therapeutic dose of the antagonist by more than 2 times and eliminated the necessity of repeated injections.
Об авторах
N. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Автор, ответственный за переписку.
Email: ng@vengerovich.ru
Россия, Moscow
M. Yudin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
V. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
A. Nikiforov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
O. Aleshina
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
A. Kuz’min
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
T. Ustinova
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Россия, Moscow
S. Gadzikovskii
Silver-Farm Innovative Pharmaceutical Companyss
Email: ng@vengerovich.ru
Россия, St. Petersburg
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