Kinetics of Mechanical Stretch-Induced Nitric Oxide Production in Rat Ventricular Cardiac Myocytes
- 作者: Shim A.1, Mitrokhin V.1, Gorbacheva L.1, Savinkova I.1, Pustovit K.1, Mladenov M.1, Kamkin A.1
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隶属关系:
- Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- 期: 卷 163, 编号 5 (2017)
- 页面: 583-585
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239107
- DOI: https://doi.org/10.1007/s10517-017-3853-4
- ID: 239107
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详细
Discrete mechanical stretch of isolated spontaneously contracting cardiac myocytes was employed to examine the kinetics of NO production in these cells. NO oscillations were detected with fluorescent dye 4-amino-5-methylamino-2’,7’-difluorofluorescein diacetate. The mechanisms underlying stretch-induced changes in NO concentration remain unclear and further studies are needed to evaluate the role of NO oscillation in the regulation of cardiomyocyte function.
作者简介
A. Shim
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
V. Mitrokhin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
L. Gorbacheva
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
I. Savinkova
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
K. Pustovit
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
M. Mladenov
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
A. Kamkin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow