Kinetics of Mechanical Stretch-Induced Nitric Oxide Production in Rat Ventricular Cardiac Myocytes
- Authors: Shim A.L.1, Mitrokhin V.M.1, Gorbacheva L.R.1, Savinkova I.G.1, Pustovit K.B.1, Mladenov M.I.1, Kamkin A.G.1
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Affiliations:
- Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 5 (2017)
- Pages: 583-585
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239107
- DOI: https://doi.org/10.1007/s10517-017-3853-4
- ID: 239107
Cite item
Abstract
Discrete mechanical stretch of isolated spontaneously contracting cardiac myocytes was employed to examine the kinetics of NO production in these cells. NO oscillations were detected with fluorescent dye 4-amino-5-methylamino-2’,7’-difluorofluorescein diacetate. The mechanisms underlying stretch-induced changes in NO concentration remain unclear and further studies are needed to evaluate the role of NO oscillation in the regulation of cardiomyocyte function.
About the authors
A. L. Shim
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
V. M. Mitrokhin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
L. R. Gorbacheva
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
I. G. Savinkova
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
K. B. Pustovit
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
M. I. Mladenov
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow
A. G. Kamkin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Russian Federation, Moscow