Kinetics of Mechanical Stretch-Induced Nitric Oxide Production in Rat Ventricular Cardiac Myocytes

A. L. Shim; V. M. Mitrokhin; L. R. Gorbacheva; I. G. Savinkova; K. B. Pustovit; M. I. Mladenov; A. G. Kamkin

doi:10.1007/s10517-017-3853-4

Kinetics of Mechanical Stretch-Induced Nitric Oxide Production in Rat Ventricular Cardiac Myocytes

Authors: Shim A.L.¹, Mitrokhin V.M.¹, Gorbacheva L.R.¹, Savinkova I.G.¹, Pustovit K.B.¹, Mladenov M.I.¹, Kamkin A.G.¹
Affiliations:
1. Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Issue: Vol 163, No 5 (2017)
Pages: 583-585
Section: Physiology
URL: https://journals.rcsi.science/0007-4888/article/view/239107
DOI: https://doi.org/10.1007/s10517-017-3853-4
ID: 239107

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Abstract

Discrete mechanical stretch of isolated spontaneously contracting cardiac myocytes was employed to examine the kinetics of NO production in these cells. NO oscillations were detected with fluorescent dye 4-amino-5-methylamino-2’,7’-difluorofluorescein diacetate. The mechanisms underlying stretch-induced changes in NO concentration remain unclear and further studies are needed to evaluate the role of NO oscillation in the regulation of cardiomyocyte function.