Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells
- 作者: Bibikova M.1, Spiridonova N.1, Korystova A.2, Kublik L.2, Levitman M.2, Shaposhnikova V.2, Korystov Y.2
-
隶属关系:
- VIORIN Company
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
- 期: 卷 163, 编号 3 (2017)
- 页面: 330-333
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238862
- DOI: https://doi.org/10.1007/s10517-017-3796-9
- ID: 238862
如何引用文章
详细
We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC50 for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.
作者简介
M. Bibikova
VIORIN Company
Email: ykorostov@rambler.ru
俄罗斯联邦, Moscow
N. Spiridonova
VIORIN Company
Email: ykorostov@rambler.ru
俄罗斯联邦, Moscow
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
俄罗斯联邦, Pushchino, Moscow region
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
俄罗斯联邦, Pushchino, Moscow region
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
俄罗斯联邦, Pushchino, Moscow region
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
俄罗斯联邦, Pushchino, Moscow region
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
编辑信件的主要联系方式.
Email: ykorostov@rambler.ru
俄罗斯联邦, Pushchino, Moscow region
![](/img/style/loading.gif)