Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells
- Авторы: Bibikova M.1, Spiridonova N.1, Korystova A.2, Kublik L.2, Levitman M.2, Shaposhnikova V.2, Korystov Y.2
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Учреждения:
- VIORIN Company
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
- Выпуск: Том 163, № 3 (2017)
- Страницы: 330-333
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238862
- DOI: https://doi.org/10.1007/s10517-017-3796-9
- ID: 238862
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Аннотация
We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC50 for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.
Об авторах
M. Bibikova
VIORIN Company
Email: ykorostov@rambler.ru
Россия, Moscow
N. Spiridonova
VIORIN Company
Email: ykorostov@rambler.ru
Россия, Moscow
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Россия, Pushchino, Moscow region
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Россия, Pushchino, Moscow region
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Россия, Pushchino, Moscow region
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Россия, Pushchino, Moscow region
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Автор, ответственный за переписку.
Email: ykorostov@rambler.ru
Россия, Pushchino, Moscow region