Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells
- Autores: Bibikova M.1, Spiridonova N.1, Korystova A.2, Kublik L.2, Levitman M.2, Shaposhnikova V.2, Korystov Y.2
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Afiliações:
- VIORIN Company
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
- Edição: Volume 163, Nº 3 (2017)
- Páginas: 330-333
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238862
- DOI: https://doi.org/10.1007/s10517-017-3796-9
- ID: 238862
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Resumo
We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC50 for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively.
Sobre autores
M. Bibikova
VIORIN Company
Email: ykorostov@rambler.ru
Rússia, Moscow
N. Spiridonova
VIORIN Company
Email: ykorostov@rambler.ru
Rússia, Moscow
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Rússia, Pushchino, Moscow region
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Rússia, Pushchino, Moscow region
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Rússia, Pushchino, Moscow region
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Email: ykorostov@rambler.ru
Rússia, Pushchino, Moscow region
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science
Autor responsável pela correspondência
Email: ykorostov@rambler.ru
Rússia, Pushchino, Moscow region
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