Cardiovascular Effects of High-Molecular-Weight Compounds of Humic Nature


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The active ingredient extracted from the peat humic substances was characterized by physicochemical parameters evaluated by UV- and IR-spectroscopy, titration, and elemental (C, H, N) analysis. The cardiovascular effects of this ingredient were examined on isolated Langendorff-perfused rat heart. It was found that the active substance in a concentration range of 0.01-0.1 mg/ml produced a vasodilating effect; in addition, it decreased the end-diastolic and left-ventricular developed pressures.

作者简介

M. Zykova

Siberian State Medical University, Ministry of Health of the Russian Federation

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Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk

M. Belousov

Siberian State Medical University, Ministry of Health of the Russian Federation

Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk

T. Lasukova

Tomsk State Pedagogical University, Ministry of Science and Education; Research Institute of Cardiology

Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk; Tomsk

A. Gorbunov

Research Institute of Cardiology

Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk

L. Logvinova

Siberian State Medical University, Ministry of Health of the Russian Federation

Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk

A. Dygai

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: gmv2@rambler.ru
俄罗斯联邦, Tomsk


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