Cardiovascular Effects of High-Molecular-Weight Compounds of Humic Nature

M. V. Zykova; M. V. Belousov; T. V. Lasukova; A. S. Gorbunov; L. A. Logvinova; A. M. Dygai

doi:10.1007/s10517-017-3767-1

Cardiovascular Effects of High-Molecular-Weight Compounds of Humic Nature

Authors: Zykova M.V.¹, Belousov M.V.¹, Lasukova T.V.²^,3, Gorbunov A.S.³, Logvinova L.A.¹, Dygai A.M.⁴
Affiliations:
1. Siberian State Medical University, Ministry of Health of the Russian Federation
2. Tomsk State Pedagogical University, Ministry of Science and Education
3. Research Institute of Cardiology
4. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Issue: Vol 163, No 2 (2017)
Pages: 206-209
Section: Pharmacology and Toxicology
URL: https://journals.rcsi.science/0007-4888/article/view/238755
DOI: https://doi.org/10.1007/s10517-017-3767-1
ID: 238755

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Abstract

The active ingredient extracted from the peat humic substances was characterized by physicochemical parameters evaluated by UV- and IR-spectroscopy, titration, and elemental (C, H, N) analysis. The cardiovascular effects of this ingredient were examined on isolated Langendorff-perfused rat heart. It was found that the active substance in a concentration range of 0.01-0.1 mg/ml produced a vasodilating effect; in addition, it decreased the end-diastolic and left-ventricular developed pressures.