Comparison of the Effects of Mitochondria-Targeted Antioxidant 10-(6’-Plastoquinonyl)Decyltriphenylphosphonium Bromide (SkQ1) and a Fragment of its Molecule Dodecyltriphenylphosphonium on Carrageenan-Induced Acute Inflammation in Mouse Model of Subcuteneous Air Pouch
- 作者: Chelombitko M.1, Averina O.2, Vasil’eva T.1, Dvorianinova E.1, Egorov M.2, Pletjushkina O.3, Popova E.3, Fedorov A.1, Romashchenko V.3, Ilyinskaya O.1
-
隶属关系:
- Biological Faculty, M. V. Lomonosov Moscow State University
- Institute of Mitoengineering, M. V. Lomonosov Moscow State University
- A. N. Belozersky Research Institute of Physicochemical Biology
- 期: 卷 162, 编号 6 (2017)
- 页面: 730-733
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238506
- DOI: https://doi.org/10.1007/s10517-017-3699-9
- ID: 238506
如何引用文章
详细
The effect of mitochondria-targeted antioxidant 10-(6’-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process.
作者简介
M. Chelombitko
Biological Faculty, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: atma69@yandex.ru
俄罗斯联邦, Moskva
O. Averina
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow
T. Vasil’eva
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moskva
E. Dvorianinova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moskva
M. Egorov
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow
O. Pletjushkina
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
俄罗斯联邦, Moscow
E. Popova
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
俄罗斯联邦, Moscow
A. Fedorov
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moskva
V. Romashchenko
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
俄罗斯联邦, Moscow
O. Ilyinskaya
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moskva