Comparison of the Effects of Mitochondria-Targeted Antioxidant 10-(6’-Plastoquinonyl)Decyltriphenylphosphonium Bromide (SkQ1) and a Fragment of its Molecule Dodecyltriphenylphosphonium on Carrageenan-Induced Acute Inflammation in Mouse Model of Subcuteneous Air Pouch
- Авторы: Chelombitko M.1, Averina O.2, Vasil’eva T.1, Dvorianinova E.1, Egorov M.2, Pletjushkina O.3, Popova E.3, Fedorov A.1, Romashchenko V.3, Ilyinskaya O.1
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Учреждения:
- Biological Faculty, M. V. Lomonosov Moscow State University
- Institute of Mitoengineering, M. V. Lomonosov Moscow State University
- A. N. Belozersky Research Institute of Physicochemical Biology
- Выпуск: Том 162, № 6 (2017)
- Страницы: 730-733
- Раздел: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238506
- DOI: https://doi.org/10.1007/s10517-017-3699-9
- ID: 238506
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Аннотация
The effect of mitochondria-targeted antioxidant 10-(6’-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process.
Об авторах
M. Chelombitko
Biological Faculty, M. V. Lomonosov Moscow State University
Автор, ответственный за переписку.
Email: atma69@yandex.ru
Россия, Moskva
O. Averina
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moscow
T. Vasil’eva
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moskva
E. Dvorianinova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moskva
M. Egorov
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moscow
O. Pletjushkina
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Россия, Moscow
E. Popova
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Россия, Moscow
A. Fedorov
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moskva
V. Romashchenko
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Россия, Moscow
O. Ilyinskaya
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Россия, Moskva