Comparison of the Effects of Mitochondria-Targeted Antioxidant 10-(6’-Plastoquinonyl)Decyltriphenylphosphonium Bromide (SkQ1) and a Fragment of its Molecule Dodecyltriphenylphosphonium on Carrageenan-Induced Acute Inflammation in Mouse Model of Subcuteneous Air Pouch
- Authors: Chelombitko M.A.1, Averina O.A.2, Vasil’eva T.V.1, Dvorianinova E.E.1, Egorov M.V.2, Pletjushkina O.Y.3, Popova E.N.3, Fedorov A.V.1, Romashchenko V.P.3, Ilyinskaya O.P.1
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Affiliations:
- Biological Faculty, M. V. Lomonosov Moscow State University
- Institute of Mitoengineering, M. V. Lomonosov Moscow State University
- A. N. Belozersky Research Institute of Physicochemical Biology
- Issue: Vol 162, No 6 (2017)
- Pages: 730-733
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238506
- DOI: https://doi.org/10.1007/s10517-017-3699-9
- ID: 238506
Cite item
Abstract
The effect of mitochondria-targeted antioxidant 10-(6’-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process.
About the authors
M. A. Chelombitko
Biological Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: atma69@yandex.ru
Russian Federation, Moskva
O. A. Averina
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moscow
T. V. Vasil’eva
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moskva
E. E. Dvorianinova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moskva
M. V. Egorov
Institute of Mitoengineering, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moscow
O. Yu. Pletjushkina
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Russian Federation, Moscow
E. N. Popova
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Russian Federation, Moscow
A. V. Fedorov
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moskva
V. P. Romashchenko
A. N. Belozersky Research Institute of Physicochemical Biology
Email: atma69@yandex.ru
Russian Federation, Moscow
O. P. Ilyinskaya
Biological Faculty, M. V. Lomonosov Moscow State University
Email: atma69@yandex.ru
Russian Federation, Moskva