Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound
- 作者: Spasov A.1, Kucheryavenko A.1, Sirotenko V.1, Gaidukova K.1, Morkovnik A.2, Anisimova V.2, Divaeva L.2, Kuz’menko T.2
-
隶属关系:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- 期: 卷 162, 编号 5 (2017)
- 页面: 636-639
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238421
- DOI: https://doi.org/10.1007/s10517-017-3675-4
- ID: 238421
如何引用文章
详细
Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
作者简介
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
A. Kucheryavenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
V. Sirotenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
K. Gaidukova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Volgograd
A. Morkovnik
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Rostov-on-Don
L. Divaeva
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Rostov-on-Don
T. Kuz’menko
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
俄罗斯联邦, Rostov-on-Don