Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound
- Авторы: Spasov A.1, Kucheryavenko A.1, Sirotenko V.1, Gaidukova K.1, Morkovnik A.2, Anisimova V.2, Divaeva L.2, Kuz’menko T.2
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Учреждения:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Выпуск: Том 162, № 5 (2017)
- Страницы: 636-639
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238421
- DOI: https://doi.org/10.1007/s10517-017-3675-4
- ID: 238421
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Аннотация
Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
Об авторах
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
A. Kucheryavenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
V. Sirotenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
K. Gaidukova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Россия, Volgograd
A. Morkovnik
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Россия, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Россия, Rostov-on-Don
L. Divaeva
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Россия, Rostov-on-Don
T. Kuz’menko
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Россия, Rostov-on-Don