Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound
- Autores: Spasov A.1, Kucheryavenko A.1, Sirotenko V.1, Gaidukova K.1, Morkovnik A.2, Anisimova V.2, Divaeva L.2, Kuz’menko T.2
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Afiliações:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Edição: Volume 162, Nº 5 (2017)
- Páginas: 636-639
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238421
- DOI: https://doi.org/10.1007/s10517-017-3675-4
- ID: 238421
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Resumo
Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
Sobre autores
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
A. Kucheryavenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
V. Sirotenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
K. Gaidukova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aidakucheryavenko@yandex.ru
Rússia, Volgograd
A. Morkovnik
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Rússia, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Rússia, Rostov-on-Don
L. Divaeva
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Rússia, Rostov-on-Don
T. Kuz’menko
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Rússia, Rostov-on-Don