Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study
- 作者: Fattakhov N.1,2, Skuratovskaya D.1, Vasilenko M.1, Kirienkova E.1, Zatolokin P.3, Mironyuk N.3, Litvinova L.1
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隶属关系:
- Immanuel Kant Baltic Federal University
- Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Regional Hospital of the Kaliningrad Region
- 期: 卷 162, 编号 5 (2017)
- 页面: 615-618
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238407
- DOI: https://doi.org/10.1007/s10517-017-3670-9
- ID: 238407
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详细
We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56, 95%CI 0.98-6.72, p=0.04) were associated with the risk of metabolic syndrome in Slavic population. Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.
作者简介
N. Fattakhov
Immanuel Kant Baltic Federal University; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad; Tomsk
D. Skuratovskaya
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad
M. Vasilenko
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad
E. Kirienkova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad
P. Zatolokin
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad
N. Mironyuk
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad
L. Litvinova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
俄罗斯联邦, Kaliningrad