Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study
- Авторы: Fattakhov N.1,2, Skuratovskaya D.1, Vasilenko M.1, Kirienkova E.1, Zatolokin P.3, Mironyuk N.3, Litvinova L.1
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Учреждения:
- Immanuel Kant Baltic Federal University
- Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Regional Hospital of the Kaliningrad Region
- Выпуск: Том 162, № 5 (2017)
- Страницы: 615-618
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238407
- DOI: https://doi.org/10.1007/s10517-017-3670-9
- ID: 238407
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Аннотация
We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56, 95%CI 0.98-6.72, p=0.04) were associated with the risk of metabolic syndrome in Slavic population. Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.
Об авторах
N. Fattakhov
Immanuel Kant Baltic Federal University; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad; Tomsk
D. Skuratovskaya
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
M. Vasilenko
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
E. Kirienkova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
P. Zatolokin
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
N. Mironyuk
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
L. Litvinova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Россия, Kaliningrad
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