Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study
- Authors: Fattakhov N.S.1,2, Skuratovskaya D.A.1, Vasilenko M.A.1, Kirienkova E.V.1, Zatolokin P.A.3, Mironyuk N.I.3, Litvinova L.S.1
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Affiliations:
- Immanuel Kant Baltic Federal University
- Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Regional Hospital of the Kaliningrad Region
- Issue: Vol 162, No 5 (2017)
- Pages: 615-618
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238407
- DOI: https://doi.org/10.1007/s10517-017-3670-9
- ID: 238407
Cite item
Abstract
We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56, 95%CI 0.98-6.72, p=0.04) were associated with the risk of metabolic syndrome in Slavic population. Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.
About the authors
N. S. Fattakhov
Immanuel Kant Baltic Federal University; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Author for correspondence.
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad; Tomsk
D. A. Skuratovskaya
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad
M. A. Vasilenko
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad
E. V. Kirienkova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad
P. A. Zatolokin
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad
N. I. Mironyuk
Regional Hospital of the Kaliningrad Region
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad
L. S. Litvinova
Immanuel Kant Baltic Federal University
Email: nikola.fattahov@mail.ru
Russian Federation, Kaliningrad