Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics
- 作者: Rodina A.1, Tenchurin T.1, Saprykin V.2, Shepelev A.1, Mamagulashvili V.1, Grigor’ev T.1, Moskaleva E.1, Chvalun S.1, Severin S.1
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隶属关系:
- National Research Center Kurchatov Institute
- A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
- 期: 卷 162, 编号 4 (2017)
- 页面: 488-495
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/238319
- DOI: https://doi.org/10.1007/s10517-017-3646-9
- ID: 238319
如何引用文章
详细
Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
作者简介
A. Rodina
National Research Center Kurchatov Institute
编辑信件的主要联系方式.
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
T. Tenchurin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
V. Saprykin
A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
A. Shepelev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
V. Mamagulashvili
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
T. Grigor’ev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
E. Moskaleva
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
S. Chvalun
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow
S. Severin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
俄罗斯联邦, Moscow