Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics
- Авторы: Rodina A.1, Tenchurin T.1, Saprykin V.2, Shepelev A.1, Mamagulashvili V.1, Grigor’ev T.1, Moskaleva E.1, Chvalun S.1, Severin S.1
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Учреждения:
- National Research Center Kurchatov Institute
- A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
- Выпуск: Том 162, № 4 (2017)
- Страницы: 488-495
- Раздел: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/238319
- DOI: https://doi.org/10.1007/s10517-017-3646-9
- ID: 238319
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Аннотация
Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
Об авторах
A. Rodina
National Research Center Kurchatov Institute
Автор, ответственный за переписку.
Email: allrodina@yandex.ru
Россия, Moscow
T. Tenchurin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
V. Saprykin
A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
Email: allrodina@yandex.ru
Россия, Moscow
A. Shepelev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
V. Mamagulashvili
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
T. Grigor’ev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
E. Moskaleva
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
S. Chvalun
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow
S. Severin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Россия, Moscow