Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics
- Authors: Rodina A.V.1, Tenchurin T.K.1, Saprykin V.P.2, Shepelev A.D.1, Mamagulashvili V.G.1, Grigor’ev T.E.1, Moskaleva E.Y.1, Chvalun S.N.1, Severin S.E.1
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Affiliations:
- National Research Center Kurchatov Institute
- A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
- Issue: Vol 162, No 4 (2017)
- Pages: 488-495
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/238319
- DOI: https://doi.org/10.1007/s10517-017-3646-9
- ID: 238319
Cite item
Abstract
Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
About the authors
A. V. Rodina
National Research Center Kurchatov Institute
Author for correspondence.
Email: allrodina@yandex.ru
Russian Federation, Moscow
T. Kh. Tenchurin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
V. P. Saprykin
A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
Email: allrodina@yandex.ru
Russian Federation, Moscow
A. D. Shepelev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
V. G. Mamagulashvili
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
T. E. Grigor’ev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
E. Yu. Moskaleva
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
S. N. Chvalun
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow
S. E. Severin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Russian Federation, Moscow