Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics
- Autores: Rodina A.1, Tenchurin T.1, Saprykin V.2, Shepelev A.1, Mamagulashvili V.1, Grigor’ev T.1, Moskaleva E.1, Chvalun S.1, Severin S.1
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Afiliações:
- National Research Center Kurchatov Institute
- A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
- Edição: Volume 162, Nº 4 (2017)
- Páginas: 488-495
- Seção: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/238319
- DOI: https://doi.org/10.1007/s10517-017-3646-9
- ID: 238319
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Resumo
Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional characteristics of mesenchymal stem cells were studied. Cell culturing on polylactide-based film and fibrous matrixes did not deteriorate cell morphology and their proliferation and differentiation capacities. The rate of cell proliferation and penetration in microporous 3D matrices with the same porosity parameters and pore size depended on their spatial organization. The above materials can be used as scaffolds for mesenchymal stem cells for creation of tissue engineering implants. The scaffold size and structure should be determined by the defects in the organs in which the regeneration processes have to be stimulated.
Sobre autores
A. Rodina
National Research Center Kurchatov Institute
Autor responsável pela correspondência
Email: allrodina@yandex.ru
Rússia, Moscow
T. Tenchurin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
V. Saprykin
A. I. Burnazyan Federal Medical and Biophysical Center, Federal Medical-Biological Agency
Email: allrodina@yandex.ru
Rússia, Moscow
A. Shepelev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
V. Mamagulashvili
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
T. Grigor’ev
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
E. Moskaleva
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
S. Chvalun
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow
S. Severin
National Research Center Kurchatov Institute
Email: allrodina@yandex.ru
Rússia, Moscow