The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy
- 作者: Kazakov O.1, Kabakov A.1, Ishchenko I.1, Poveshchenko A.1, Raiter T.1, Strunkin D.1, Michurina S.1, Konenkov V.1
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隶属关系:
- Research Institute of Clinical and Experimental Lymphology
- 期: 卷 162, 编号 4 (2017)
- 页面: 479-482
- 栏目: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238312
- DOI: https://doi.org/10.1007/s10517-017-3644-y
- ID: 238312
如何引用文章
详细
Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
作者简介
O. Kazakov
Research Institute of Clinical and Experimental Lymphology
编辑信件的主要联系方式.
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
A. Kabakov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
A. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
T. Raiter
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
D. Strunkin
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
V. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
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