The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy
- Авторлар: Kazakov O.1, Kabakov A.1, Ishchenko I.1, Poveshchenko A.1, Raiter T.1, Strunkin D.1, Michurina S.1, Konenkov V.1
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Мекемелер:
- Research Institute of Clinical and Experimental Lymphology
- Шығарылым: Том 162, № 4 (2017)
- Беттер: 479-482
- Бөлім: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238312
- DOI: https://doi.org/10.1007/s10517-017-3644-y
- ID: 238312
Дәйексөз келтіру
Аннотация
Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
Авторлар туралы
O. Kazakov
Research Institute of Clinical and Experimental Lymphology
Хат алмасуға жауапты Автор.
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
A. Kabakov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
A. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
T. Raiter
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
D. Strunkin
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk
V. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Ресей, Novosibirsk