The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy
- Authors: Kazakov O.V.1, Kabakov A.V.1, Ishchenko I.Y.1, Poveshchenko A.F.1, Raiter T.V.1, Strunkin D.N.1, Michurina S.V.1, Konenkov V.I.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- Issue: Vol 162, No 4 (2017)
- Pages: 479-482
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238312
- DOI: https://doi.org/10.1007/s10517-017-3644-y
- ID: 238312
Cite item
Abstract
Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
About the authors
O. V. Kazakov
Research Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. V. Kabakov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
I. Yu. Ishchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. F. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
T. V. Raiter
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
D. N. Strunkin
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
S. V. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk