The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy
- Авторы: Kazakov O.1, Kabakov A.1, Ishchenko I.1, Poveshchenko A.1, Raiter T.1, Strunkin D.1, Michurina S.1, Konenkov V.1
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Учреждения:
- Research Institute of Clinical and Experimental Lymphology
- Выпуск: Том 162, № 4 (2017)
- Страницы: 479-482
- Раздел: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238312
- DOI: https://doi.org/10.1007/s10517-017-3644-y
- ID: 238312
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Аннотация
Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
Об авторах
O. Kazakov
Research Institute of Clinical and Experimental Lymphology
Автор, ответственный за переписку.
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
A. Kabakov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
A. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
T. Raiter
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
D. Strunkin
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk
V. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Россия, Novosibirsk