Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension
- 作者: Plotnikov M.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Anishchenko A.1, Nosarev A.2, Pushkina E.2
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隶属关系:
- Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Department of Biophysics and Functional Diagnostics, Siberian State Medical University
- 期: 卷 162, 编号 3 (2017)
- 页面: 353-356
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238199
- DOI: https://doi.org/10.1007/s10517-017-3614-4
- ID: 238199
如何引用文章
详细
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10—8-10—6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.
作者简介
M. Plotnikov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
编辑信件的主要联系方式.
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
O. Aliev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Sidekhmenova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Shamanaev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Anishchenko
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
A. Nosarev
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
E. Pushkina
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
俄罗斯联邦, Tomsk
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