Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension
- Authors: Plotnikov M.B.1, Aliev O.I.1, Sidekhmenova A.V.1, Shamanaev A.Y.1, Anishchenko A.M.1, Nosarev A.V.2, Pushkina E.A.2
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Affiliations:
- Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Department of Biophysics and Functional Diagnostics, Siberian State Medical University
- Issue: Vol 162, No 3 (2017)
- Pages: 353-356
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238199
- DOI: https://doi.org/10.1007/s10517-017-3614-4
- ID: 238199
Cite item
Abstract
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10—8-10—6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.
About the authors
M. B. Plotnikov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: mbp2001@mail.ru
Russian Federation, Tomsk
O. I. Aliev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. V. Sidekhmenova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. Yu. Shamanaev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. M. Anishchenko
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Russian Federation, Tomsk
A. V. Nosarev
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Russian Federation, Tomsk
E. A. Pushkina
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Russian Federation, Tomsk