Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension
- Авторы: Plotnikov M.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Anishchenko A.1, Nosarev A.2, Pushkina E.2
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Учреждения:
- Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Department of Biophysics and Functional Diagnostics, Siberian State Medical University
- Выпуск: Том 162, № 3 (2017)
- Страницы: 353-356
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238199
- DOI: https://doi.org/10.1007/s10517-017-3614-4
- ID: 238199
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Аннотация
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10—8-10—6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.
Об авторах
M. Plotnikov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Автор, ответственный за переписку.
Email: mbp2001@mail.ru
Россия, Tomsk
O. Aliev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Россия, Tomsk
A. Sidekhmenova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Россия, Tomsk
A. Shamanaev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Россия, Tomsk
A. Anishchenko
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Россия, Tomsk
A. Nosarev
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Россия, Tomsk
E. Pushkina
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Россия, Tomsk
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