Modes of Hypotensive Action of Dihydroquercetin in Arterial Hypertension
- Autores: Plotnikov M.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Anishchenko A.1, Nosarev A.2, Pushkina E.2
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Afiliações:
- Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Department of Biophysics and Functional Diagnostics, Siberian State Medical University
- Edição: Volume 162, Nº 3 (2017)
- Páginas: 353-356
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238199
- DOI: https://doi.org/10.1007/s10517-017-3614-4
- ID: 238199
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Resumo
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change. In in vitro experiments, dihydroquercetin (10—8-10—6M) induced relaxation of the isolated thoracic aorta rings in a dose-dependent manner. Hence, the antihypertensive effect of dihydroquercetin results from the decrease in blood viscosity and vasodilation.
Sobre autores
M. Plotnikov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Autor responsável pela correspondência
Email: mbp2001@mail.ru
Rússia, Tomsk
O. Aliev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Sidekhmenova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Shamanaev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Anishchenko
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Nosarev
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Rússia, Tomsk
E. Pushkina
Department of Biophysics and Functional Diagnostics, Siberian State Medical University
Email: mbp2001@mail.ru
Rússia, Tomsk
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