Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds
- 作者: Zabrodskii P.1, Maslyakov V.1, Gromov M.1
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隶属关系:
- Saratov Branch of the Samara Medical Institute REAVIZ
- 期: 卷 161, 编号 6 (2016)
- 页面: 779-781
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237769
- DOI: https://doi.org/10.1007/s10517-016-3508-x
- ID: 237769
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详细
Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.
作者简介
P. Zabrodskii
Saratov Branch of the Samara Medical Institute REAVIZ
编辑信件的主要联系方式.
Email: pfzabrodsky@gmail.com
俄罗斯联邦, Saratov
V. Maslyakov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
俄罗斯联邦, Saratov
M. Gromov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
俄罗斯联邦, Saratov