Email this article Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds
- Authors: Zabrodskii P.F.1, Maslyakov V.V.1, Gromov M.S.1
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Affiliations:
- Saratov Branch of the Samara Medical Institute REAVIZ
- Issue: Vol 161, No 6 (2016)
- Pages: 779-781
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237769
- DOI: https://doi.org/10.1007/s10517-016-3508-x
- ID: 237769
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Abstract
Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.
About the authors
P. F. Zabrodskii
Saratov Branch of the Samara Medical Institute REAVIZ
Author for correspondence.
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
V. V. Maslyakov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
M. S. Gromov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
