Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds
- Autores: Zabrodskii P.1, Maslyakov V.1, Gromov M.1
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Afiliações:
- Saratov Branch of the Samara Medical Institute REAVIZ
- Edição: Volume 161, Nº 6 (2016)
- Páginas: 779-781
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237769
- DOI: https://doi.org/10.1007/s10517-016-3508-x
- ID: 237769
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Resumo
Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.
Sobre autores
P. Zabrodskii
Saratov Branch of the Samara Medical Institute REAVIZ
Autor responsável pela correspondência
Email: pfzabrodsky@gmail.com
Rússia, Saratov
V. Maslyakov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Rússia, Saratov
M. Gromov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Rússia, Saratov