Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds
- Авторлар: Zabrodskii P.1, Maslyakov V.1, Gromov M.1
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Мекемелер:
- Saratov Branch of the Samara Medical Institute REAVIZ
- Шығарылым: Том 161, № 6 (2016)
- Беттер: 779-781
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237769
- DOI: https://doi.org/10.1007/s10517-016-3508-x
- ID: 237769
Дәйексөз келтіру
Аннотация
Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of α7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP.
Авторлар туралы
P. Zabrodskii
Saratov Branch of the Samara Medical Institute REAVIZ
Хат алмасуға жауапты Автор.
Email: pfzabrodsky@gmail.com
Ресей, Saratov
V. Maslyakov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Ресей, Saratov
M. Gromov
Saratov Branch of the Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Ресей, Saratov