Cardioprotective Effect of Modified Peroxiredoxins in Retrograde Perfusion of Isolated Rat Heart under Conditions of Oxidative Stress
- 作者: Karaduleva E.1, Mubarakshina E.1, Sharapov M.1, Volkova A.1, Pimenov O.1,2, Ravin V.1, Kokoz Y.1,2, Novoselov V.1
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隶属关系:
- Institute of Cell Biophysics, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- 期: 卷 160, 编号 5 (2016)
- 页面: 639-642
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236854
- DOI: https://doi.org/10.1007/s10517-016-3237-1
- ID: 236854
如何引用文章
详细
Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotective properties manifested in heart rate normalization, maintenance of contractile activity of the myocardium, and prevention of H2O2-induced LPO in oxidative stress. Localization of peroxiredoxin-6 and PSH in the cardiac tissue was determined and myocardial structures most effectively protected by the antioxidant enzymes from ischemia/reperfusion-induced damages were identified. The results suggest that modified peroxiredoxins are promising components of perfusion media for preservation of isolated organs.
作者简介
E. Karaduleva
Institute of Cell Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino
E. Mubarakshina
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino
A. Volkova
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino
O. Pimenov
Institute of Cell Biophysics, Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino; Pushchino, Moscow Region
V. Ravin
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino
Yu. Kokoz
Institute of Cell Biophysics, Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino; Pushchino, Moscow Region
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
俄罗斯联邦, Pushchino