Cardioprotective Effect of Modified Peroxiredoxins in Retrograde Perfusion of Isolated Rat Heart under Conditions of Oxidative Stress
- Авторлар: Karaduleva E.1, Mubarakshina E.1, Sharapov M.1, Volkova A.1, Pimenov O.1,2, Ravin V.1, Kokoz Y.1,2, Novoselov V.1
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Мекемелер:
- Institute of Cell Biophysics, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Шығарылым: Том 160, № 5 (2016)
- Беттер: 639-642
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236854
- DOI: https://doi.org/10.1007/s10517-016-3237-1
- ID: 236854
Дәйексөз келтіру
Аннотация
Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotective properties manifested in heart rate normalization, maintenance of contractile activity of the myocardium, and prevention of H2O2-induced LPO in oxidative stress. Localization of peroxiredoxin-6 and PSH in the cardiac tissue was determined and myocardial structures most effectively protected by the antioxidant enzymes from ischemia/reperfusion-induced damages were identified. The results suggest that modified peroxiredoxins are promising components of perfusion media for preservation of isolated organs.
Авторлар туралы
E. Karaduleva
Institute of Cell Biophysics, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino
E. Mubarakshina
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino
M. Sharapov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino
A. Volkova
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino
O. Pimenov
Institute of Cell Biophysics, Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino; Pushchino, Moscow Region
V. Ravin
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino
Yu. Kokoz
Institute of Cell Biophysics, Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino; Pushchino, Moscow Region
V. Novoselov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: e.v.karaduleva@gmail.com
Ресей, Pushchino