N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
- 作者: Neganova M.1, Proshin A.1, Redkozubova O.1, Serkov I.1, Serkova T.1, Dubova L.1, Shevtsova E.1
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隶属关系:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- 期: 卷 160, 编号 3 (2016)
- 页面: 340-342
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236701
- DOI: https://doi.org/10.1007/s10517-016-3165-0
- ID: 236701
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详细
Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N’-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N’-substituted selenourea analogs.
作者简介
M. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
A. Proshin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
O. Redkozubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
I. Serkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
T. Serkova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
L. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
俄罗斯联邦, Chernogolovka
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