N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
- Autores: Neganova M.1, Proshin A.1, Redkozubova O.1, Serkov I.1, Serkova T.1, Dubova L.1, Shevtsova E.1
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Afiliações:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Edição: Volume 160, Nº 3 (2016)
- Páginas: 340-342
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236701
- DOI: https://doi.org/10.1007/s10517-016-3165-0
- ID: 236701
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Resumo
Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N’-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N’-substituted selenourea analogs.
Sobre autores
M. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Autor responsável pela correspondência
Email: neganova83@mail.ru
Rússia, Chernogolovka
A. Proshin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
O. Redkozubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
I. Serkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
T. Serkova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
L. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Rússia, Chernogolovka