N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
- Authors: Neganova M.E.1, Proshin A.N.1, Redkozubova O.M.1, Serkov I.V.1, Serkova T.P.1, Dubova L.G.1, Shevtsova E.F.1
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Affiliations:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 160, No 3 (2016)
- Pages: 340-342
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236701
- DOI: https://doi.org/10.1007/s10517-016-3165-0
- ID: 236701
Cite item
Abstract
Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N’-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N’-substituted selenourea analogs.
About the authors
M. E. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
A. N. Proshin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
O. M. Redkozubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
I. V. Serkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
T. P. Serkova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
L. G. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka
E. F. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Russian Federation, Chernogolovka