N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
- Авторы: Neganova M.1, Proshin A.1, Redkozubova O.1, Serkov I.1, Serkova T.1, Dubova L.1, Shevtsova E.1
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Учреждения:
- Institute of Physiologically Active Substances, Russian Academy of Sciences
- Выпуск: Том 160, № 3 (2016)
- Страницы: 340-342
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236701
- DOI: https://doi.org/10.1007/s10517-016-3165-0
- ID: 236701
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Аннотация
Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N’-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N’-substituted selenourea analogs.
Об авторах
M. Neganova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: neganova83@mail.ru
Россия, Chernogolovka
A. Proshin
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
O. Redkozubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
I. Serkov
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
T. Serkova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
L. Dubova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka
E. Shevtsova
Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: neganova83@mail.ru
Россия, Chernogolovka