Calcium Salt of N-(5-Hydroxynicotinoyl)-L-Glutamic Acid Weakens Depressive-Like Behavior and Parkinsonian Syndrome in Experiment on Rodents
- Авторы: Kiselev A.1, Vedenkin A.1, Stovbun I.2, Sergienko V.3, Kalinina T.2
-
Учреждения:
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
- V. V. Zakusov Research Institute of Pharmacology
- Federal Research and Clinical Center for Physicochemical Medicine, Federal Medical-Biological Agency of Russia
- Выпуск: Том 168, № 1 (2019)
- Страницы: 48-51
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242191
- DOI: https://doi.org/10.1007/s10517-019-04643-5
- ID: 242191
Цитировать
Аннотация
We studied antidepressant and antiparkinsonian properties of N-(5-hydroxynicotinoyl)-Lglutamic acid calcium salt (Ampasse) in rodents. It was found that Ampasse in a dose of 30 mg/kg exhibited antidepressant activity in the forced swimming test in mice and in a dose of 0.1 mg/kg maximally alleviates the symptoms of parkinsonian syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57Bl/6 mice, and haloperidol-induced catalepsy in rats.
Об авторах
A. Kiselev
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
Автор, ответственный за переписку.
Email: alexey_k@panavir.ru
Россия, Moscow
A. Vedenkin
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
Email: alexey_k@panavir.ru
Россия, Moscow
I. Stovbun
V. V. Zakusov Research Institute of Pharmacology
Email: alexey_k@panavir.ru
Россия, Moscow
V. Sergienko
Federal Research and Clinical Center for Physicochemical Medicine, Federal Medical-Biological Agency of Russia
Email: alexey_k@panavir.ru
Россия, Moscow
T. Kalinina
V. V. Zakusov Research Institute of Pharmacology
Email: alexey_k@panavir.ru
Россия, Moscow
![](/img/style/loading.gif)