Calcium Salt of N-(5-Hydroxynicotinoyl)-L-Glutamic Acid Weakens Depressive-Like Behavior and Parkinsonian Syndrome in Experiment on Rodents

A. V. Kiselev; A. S. Vedenkin; I. S. Stovbun; V. I. Sergienko; T. S. Kalinina

doi:10.1007/s10517-019-04643-5

Calcium Salt of N-(5-Hydroxynicotinoyl)-L-Glutamic Acid Weakens Depressive-Like Behavior and Parkinsonian Syndrome in Experiment on Rodents

Авторлар: Kiselev A.¹, Vedenkin A.¹, Stovbun I.², Sergienko V.³, Kalinina T.²
Мекемелер:
1. N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
2. V. V. Zakusov Research Institute of Pharmacology
3. Federal Research and Clinical Center for Physicochemical Medicine, Federal Medical-Biological Agency of Russia
Шығарылым: Том 168, № 1 (2019)
Беттер: 48-51
Бөлім: Article
URL: https://journals.rcsi.science/0007-4888/article/view/242191
DOI: https://doi.org/10.1007/s10517-019-04643-5
ID: 242191

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Аннотация

We studied antidepressant and antiparkinsonian properties of N-(5-hydroxynicotinoyl)-Lglutamic acid calcium salt (Ampasse) in rodents. It was found that Ampasse in a dose of 30 mg/kg exhibited antidepressant activity in the forced swimming test in mice and in a dose of 0.1 mg/kg maximally alleviates the symptoms of parkinsonian syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57Bl/6 mice, and haloperidol-induced catalepsy in rats.