Email this article Calcium Salt of N-(5-Hydroxynicotinoyl)-L-Glutamic Acid Weakens Depressive-Like Behavior and Parkinsonian Syndrome in Experiment on Rodents
- Authors: Kiselev A.V.1, Vedenkin A.S.1, Stovbun I.S.2, Sergienko V.I.3, Kalinina T.S.2
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Affiliations:
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
- V. V. Zakusov Research Institute of Pharmacology
- Federal Research and Clinical Center for Physicochemical Medicine, Federal Medical-Biological Agency of Russia
- Issue: Vol 168, No 1 (2019)
- Pages: 48-51
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242191
- DOI: https://doi.org/10.1007/s10517-019-04643-5
- ID: 242191
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Abstract
We studied antidepressant and antiparkinsonian properties of N-(5-hydroxynicotinoyl)-Lglutamic acid calcium salt (Ampasse) in rodents. It was found that Ampasse in a dose of 30 mg/kg exhibited antidepressant activity in the forced swimming test in mice and in a dose of 0.1 mg/kg maximally alleviates the symptoms of parkinsonian syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57Bl/6 mice, and haloperidol-induced catalepsy in rats.
About the authors
A. V. Kiselev
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
Author for correspondence.
Email: alexey_k@panavir.ru
Russian Federation, Moscow
A. S. Vedenkin
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science
Email: alexey_k@panavir.ru
Russian Federation, Moscow
I. S. Stovbun
V. V. Zakusov Research Institute of Pharmacology
Email: alexey_k@panavir.ru
Russian Federation, Moscow
V. I. Sergienko
Federal Research and Clinical Center for Physicochemical Medicine, Federal Medical-Biological Agency of Russia
Email: alexey_k@panavir.ru
Russian Federation, Moscow
T. S. Kalinina
V. V. Zakusov Research Institute of Pharmacology
Email: alexey_k@panavir.ru
Russian Federation, Moscow
