Quantitative and Qualitative Characterization of Phagocytic Activity of Macrophages of Bone Marrow and Fetal Origin
- Авторы: Lokhonina A.1,2, Makarov A.1,3, Elchaninov A.1,2, Arutyunyan I.1,4, Shmakova T.4, Grinberg M.2, Usman N.1, Surovtsev V.2, Chernikov V.4, Fatkhudinov T.1,2
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Учреждения:
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Research Institute of Human Morphology, Research Institute of Human Morphology
- Выпуск: Том 167, № 1 (2019)
- Страницы: 154-158
- Раздел: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241535
- DOI: https://doi.org/10.1007/s10517-019-04481-5
- ID: 241535
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Аннотация
We compared phagocytic activity of macrophages of monocyte origin and Kupffer cells under the influence of M1 and M2 inducers and without activation. Cultures of monocyte-derived macrophages and Kupffer cells were characterized by intensive expression of CD68 that was not affected by activation factors. At the same time, these cultures demonstrated different dynamics of phagocytic activity. Monocyte-derived macrophages initially had more pronounced absorption capacity that gradually increased during the experiment. Kupffer cells were characterized by abrupt fluctuations of phagocytic activity: sharp growth and rapid saturation. Despite these differences, the endosomes produced by monocyte-derived macrophages and Kupffer cells had similar degrees of maturity.
Об авторах
A. Lokhonina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
Россия, Moscow; Moscow
A. Makarov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: elchandrey@yandex.ru
Россия, Moscow; Moscow
A. Elchaninov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Автор, ответственный за переписку.
Email: elchandrey@yandex.ru
Россия, Moscow; Moscow
I. Arutyunyan
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
Россия, Moscow; Moscow
T. Shmakova
Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
Россия, Moscow
M. Grinberg
Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
Россия, Moscow
N. Usman
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: elchandrey@yandex.ru
Россия, Moscow
V. Surovtsev
Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
Россия, Moscow
V. Chernikov
Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
Россия, Moscow
T. Fatkhudinov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
Россия, Moscow; Moscow