Quantitative and Qualitative Characterization of Phagocytic Activity of Macrophages of Bone Marrow and Fetal Origin
- 作者: Lokhonina A.1,2, Makarov A.1,3, Elchaninov A.1,2, Arutyunyan I.1,4, Shmakova T.4, Grinberg M.2, Usman N.1, Surovtsev V.2, Chernikov V.4, Fatkhudinov T.1,2
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隶属关系:
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Research Institute of Human Morphology, Research Institute of Human Morphology
- 期: 卷 167, 编号 1 (2019)
- 页面: 154-158
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241535
- DOI: https://doi.org/10.1007/s10517-019-04481-5
- ID: 241535
如何引用文章
详细
We compared phagocytic activity of macrophages of monocyte origin and Kupffer cells under the influence of M1 and M2 inducers and without activation. Cultures of monocyte-derived macrophages and Kupffer cells were characterized by intensive expression of CD68 that was not affected by activation factors. At the same time, these cultures demonstrated different dynamics of phagocytic activity. Monocyte-derived macrophages initially had more pronounced absorption capacity that gradually increased during the experiment. Kupffer cells were characterized by abrupt fluctuations of phagocytic activity: sharp growth and rapid saturation. Despite these differences, the endosomes produced by monocyte-derived macrophages and Kupffer cells had similar degrees of maturity.
作者简介
A. Lokhonina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow; Moscow
A. Makarov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow; Moscow
A. Elchaninov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
编辑信件的主要联系方式.
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow; Moscow
I. Arutyunyan
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow; Moscow
T. Shmakova
Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow
M. Grinberg
Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow
N. Usman
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow
V. Surovtsev
Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow
V. Chernikov
Research Institute of Human Morphology, Research Institute of Human Morphology
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow
T. Fatkhudinov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Email: elchandrey@yandex.ru
俄罗斯联邦, Moscow; Moscow
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