Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin
- Авторы: Vasin M.1, Gan’shina T.2, Mirzoyan R.2, Semenova L.1, Koroleva L.1, Afanas’ev R.1, Ushakov I.1
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Учреждения:
- State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- V. V. Zakusov Research Institute of Pharmacology
- Выпуск: Том 165, № 3 (2018)
- Страницы: 364-367
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240312
- DOI: https://doi.org/10.1007/s10517-018-4171-1
- ID: 240312
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Аннотация
We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector.
Об авторах
M. Vasin
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Автор, ответственный за переписку.
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
T. Gan’shina
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
R. Mirzoyan
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
L. Semenova
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
L. Koroleva
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
R. Afanas’ev
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow
I. Ushakov
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Россия, Moscow