Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin
- Авторлар: Vasin M.1, Gan’shina T.2, Mirzoyan R.2, Semenova L.1, Koroleva L.1, Afanas’ev R.1, Ushakov I.1
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Мекемелер:
- State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 165, № 3 (2018)
- Беттер: 364-367
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240312
- DOI: https://doi.org/10.1007/s10517-018-4171-1
- ID: 240312
Дәйексөз келтіру
Аннотация
We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector.
Авторлар туралы
M. Vasin
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Хат алмасуға жауапты Автор.
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
T. Gan’shina
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
R. Mirzoyan
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
L. Semenova
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
L. Koroleva
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
R. Afanas’ev
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
I. Ushakov
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Ресей, Moscow
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